Cesium-131 by Isoray is a Smart Choice for All Types of Brachytherapy.

Brachytherapy with Cesium-131 by Isoray is yielding great outcomes. Learn more here and reach out to us for more information.

Cesium-131 by Isoray is a Smart Choice for All Types of Brachytherapy.

Brachytherapy with Cesium-131 by Isoray is yielding great outcomes. Learn more here and reach out to us for more information.

Years of Data

Patients Treated

Cesium-131 Findings in Brachytherapy Research

Brain

Neurocognitive function and quality of life in patients with newly diagnosed brain metastasis after treatment with intra-operative cesium-131 brachytherapy: a prospective trial

Author: Pham, A, et al., J Neurooncology Dec 2015 (Dec)

Summary: Intraoperative placement of Cs131 provides a viable alterantive to WBRT.  This study reports the outcomes of 24 patients treated with Cs 131 after surgical resection

Reference: DOI 10.1007/s11060-015-2009-5

The cost-effectiveness of surgical resection and cesium-131 intraoperative brachytherapy versus surgical resection and stereotactic radiosurgery in the treatment of metastatic brain tumors

Author: Wernicke, AG, et al., J Neurooncology, Jan 2016

Summary: Compares the cost-effectiveness of Cs-131 versus SRT for radiation delivery following surgery for the treatment of brain metasteses.

Reference: DOI 10.1007/s11060-015-2026-4

Phase I/II study of resection and intraoperative cesium-131 radioisotope brachytherapy in patients with newly diagnosed brain metastases

Author: Wernicke, AG, et al., J Neurosurg, May 2, 2014

Summary: This study of 24 patients with brain metastases resulting in no local recurrence, and no radiation necrosis

Reference: http://thejns.org/doi/abs/10.3171/2014.3.JNS131140

Surgical Technique and Clinically Relevant Resection Cavity Dynamics Following Implantation of Cesium-131 Brachytherapy in Patients With Brain Metastases

Author: Wernicke, AG, et al., OPERATIVE NEUROSURGERY, 0:1–11, 2015 DOI: 10.1227

Summary: Technique to deliver Cs-131 following surgery for brain metasteses

Reference: DOI: 10.1227/NEU.0000000000000986

Prostate

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Cesium131 Prostate Brachytherapy: An early experience” B. Moran, Brachytherapy 2007;6(2):80

Dr. Moran from Chicago reports on 104 patients implanted with Cesium-131 for localized prostate cancer.  Serum PSAs in these patients dropped precipitously as expected given the typical response of PSA to successful brachytherapy.  Patient-reported urinary symptoms had returned to pre-treatment levels in the great majority of patients by six months, which may represent an advantage over other brachytherapy isotopes.

Clinical Outcomes of a Phase II, Multi-Institutional Cesium-131 Premanent Prostate Brachytherapy Trial“, B. Prestidge, Brachytherapy 2007;6(2):78.
Dr. Prestidge, from San Antonio, reported in 2007 on the ground-breaking 100-patient clinical study known as the “Cesium Monotherapy Trial.”They noted only one (1%) RTOG grade 3 rectal complication, and also noted the duration of urinary side-effects to last approximately six months.  Symptoms were statistically correlated to the dose of Cs-131 delivered.

Dosimetric Evaluation of Permanent Prostate Brachytherapy Using Cs-131 Sources” by Steven Kurtzman, M.D. Int. J. Radiation Oncology Biol. Phys.;66(3):S395.
Dr. Kurtzman, of San Mateo, California, studied the dosimetry of 58 patients implanted with Cs-131.  He noted the dose “inhomogeneity” – as measured by the dosimetric concept “V150” – to be very low as compared to other brachytherapy isotopes.

“Cesium-131 Permanent Prostate Brachytherapy: An Initial Report.” Prestidge B.R., Bice W.S., Jurkovic I., et al. “, Int. J. Radiation Oncology Biol. Phys. 2005; 63 (1): 5336-5337.

In the first report related to the Cesium Monotherapy Trial (see above), Dr. Prestidge reports in 2005 on the first large scale Cesium study, including overall doses delivered, activity implanted, and resultant dosimetric parameters.

“Is There a Decreased Duration of Acute Urinary and Bowel Symptoms after Prostate Brachytherapy with Cesium 131 Isotope?” DeFoe SG, et al.  Int. J. Radiation Oncology Biol. Phys. 2008;72(S1):S317
Dr. DeFoe, from the University of Pittsburgh, reports on a series of 94 patients treated with Cesium-131 prostate brachytherapy.  In agreement with other, similar, studies, the Cesium treated patients overcome brachytherapy-related urinary symptoms within six months.  Their data suggests an early cessation of urinary side effects because of the short half-life of Cesium-131.

“Point: Cesium-131: Ready for Prime Time.” Bice WS.  Brachytherapy 2009;8(1):1-3.
Dr. Bice argues that the potential advantages of Cesium-131 prostate brachytherapy are important to consider – especially to a clinical culture that may not be interested in a “new” brachytherapy isotope.

“IPSS Trends for Cs-131 Permanent Prostate Brachytherapy.” Jones A, et al.  Brachytherapy 2008;7(2):194.
Dr. Jones from Danville, PA, reports on 90 patients with prostate cancer treated with Cesium-131 brachytherapy.  He and his colleagues conclude that the short half-life of Cesium-131 contributes to a shorter duration of the typical urinary side-effects of brachytherapy.

“Early Outcomes of Prostate Seed Implants with 131Cs: Toxicity and Initial PSA Dynamics from a Single Institution.” Platta CS, et al.  Int. J. Radiation Oncology Biol. Phys. 2008;72(S1):S323-4.
Dr. Platta from the University of Wisconsin describes the outcomes of 67 patients treated with Cesium-131 prostate brachytherapy. He reports that the rate of PSA decline following treatment with Cesium-131 may be faster than for other brachytherapy radioisotopes.  Because of the quick resolution of urinary side effects, Dr. Platta and his colleagues call for larger scale studies into Cesium-131 prostate brachytherapy.

“Is There Decreased Duration of Acute Urinary and Bowel Symptoms After Prostate Brachytherapy with Cesium 131 Radioisotope?”
View Abstract

Dosimetric Comparison of Cesium-l3l and Palladium-103 for Permanent Prostate Brachytherapy View Abstract

Is Cesium–l3l, I-125 or Pd-103 the Ideal Isotope for Prostate Boost Brachytherapy: A Dosimetric Viewpoint View Abstract

IPSS Score Trends for Cs-131 Permanent Prostate Brachytherapy View Abstract

Lung

Allen MS, Darling GE, Pechet TT, et al. Morbidity and mortality of major pulmonary resections in patients with early-stage lung cancer; initial results of the randomized, prospective ACOSOG Z0030 trial. Ann Thorac Surg 2006;81:1013e1019.

Ginsberg RJ, Rubinstein LV. Lung Cancer Study Group. Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Ann Thorac Surg 1995;60:615e622.

Chen A, Galloway M, Landreneau R, et al. Intraoperative 125I brachytherapy for high-risk stage I non-small cell lung carcinoma. Int J Radiat Oncol Biol Phys 1999;44:1057e1063.

Shibamoto Y, Hashizume C, Baba F, et al. Stereotactic body radiotherapy using a radiobiology-based regimen for stage I non- small cell lung cancer: A multicenter study.Cancer 2012;118:2078e2084.

Timmerman R, Paulus R, Galvin J, et al. Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA 2010;303:

Haasbeek CJ, Lagerwaard FJ, Slotman BJ, Senan S. Outcomes of stereotactic ablative radiotherapy for centrally located early-stage lung cancer. J Thorac Oncol 2011;6:2036e2043.

Baumann P, Nyman J, Hoyer M, et al. Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy. J Clin Oncol 2009;27:3290e3296.

Mohiuddin K, Haneuse S, Sofer T, et al. Relationship between margin distance and local recurrence among patients undergoing wedge resection for small (#2 cm) non-small cell lung cancer. J Thorac Cardiovasc Surg 2014;147:1169e1175.

Fernando HC, Landreneau RJ, Mandrekar SJ, et al. Impact of brachytherapy on local recurrence rates after sublobar resection: Results from ACOSOG Z4032 (Alliance), a phase III randomized trial for high-risk operable non-small-cell lung cancer. J Clin Oncol 2014;32:2456e2462.1070e1076.

Mery, “Similar long term survival of elderly patients with Non small cell lung cancer treated with lobectomy or wedge resection within the surveillance, epidemiology, and end results database” chest, 2005, 128; 237-245

Bach, “Racial differences in the treatment of early stage non small cell lung cancer NEJM, 1999, 341, 1198-205

Gynecological

Implementation and early clinical results utilizing Cs-131 permanent interstitial implants for gynecologic malignancies.

Gynecol Oncol. 2014 May;133(2):268-73. doi: 10.1016/j.ygyno.2014.02.015. Epub 2014 Feb 17.
Wooten CE, Randall M, Edwards J, Aryal P, Luo W, Feddock J

Outpatient Interstitial Implants – Integrating Cesium-131 Permanent Interstitial Brachytherapy into Definitive Treatment for Gynecologic Malignancies 

Permanent interstitial reirradiation with Au-198 seeds in patients with post-radiation locally recurrent uterine carcinoma.

J Radiat Res. 2013 Mar; 54(2): 299–306.
Okazawa K, Yuasa-Nakagawa K, Yoshimura R, Shibuya H.

Cesium

The Determination of Radiobiologically Optimized Half-lives for Radionuclides Used in Permanent Brachytherapy Implants.” by Armpilia CI, Dale RG, Coles IP, et al., Int. J. Radiation Oncology Biol. Phys. 2003; 55 (2): 378-385.

Dr. Armpilia reports on and derives equations for the formal mathematics of Biologic Effective Dose.  According to the mathematical models that take into account variables related to the ability of certain cancers to grow aggressively even while being irradiated, Dr. Armpilia concludes that Cs-131 will successfully treat a wider range of possible cancer types than other brachytherapy isotopes.

Cs-131 Prostate Brachytherapy and Treatment Plan Parameters.” Sutlief S and Wallner K.  Medical Physics 2007; 34(6):2431.
Drs. Sutlief and Wallner from Seattle report on a dosimetric study of Cesium-131 implants.  They conclude that Cesium implants result in fewer “hotspots” than the other isotopes, are resistant to small errors in source placement, and require fewer seeds for large prostates.

Is Cs-131 or I-125 or Pd-103 the Ideal Isotope for Prostate Boost Brachytherapy? A Dosimetric View Point.” Yaparpalvi R, et al.  Int. J. Radiation Oncology Biol. Phys. 2007;69(3):S677-8
Dr. Yaparpalvi from New York City runs a dosimetric study that reveals advantages to Cesium prostate brachytherapy over brachytherapy with other available isotopes.  Again, the homogeneity of dose and the very low rate of “hot spots” are highly attractive from a dosimetric point of view.

“Dosimetric Comparison of Cesium-131 and Palladium-103 for Permanent Prostate Brachytherapy.” Musmacher JS, et al.  Int. J. Radiation Oncology Biol. Phys. 2007;69(3):S730-1.
Mr. Musmacher and his physician colleagues (Smithtown, NY) report that Cesium-131 delivers a more homogenous dosimetric profile than Palladium-103, while maintaining essentially equivalent gland coverage.

* Compared to other isotopes commonly used in permanent seed brachytherapy for prostate cancer

Learn about how Cesium-131 by Isoray is being used in radiation treatment.

Doctors around the country use Cesium-131 by Isoray to treat a wide range of cancers.

Prostate

Over 10,000 patients treated.

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Brain

A novel approach for radiation delivery.

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Gynecological

An innovative solution for recurrent cancers.

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Head & Neck

Delivering personalized radiation to tightly controlled areas.

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Lung

Customized individual cancer treatment.

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Breakthroughs in brachytherapy by Cesium Pioneers.

Doctors across the US are using Cesium-131 by Isoray in powerful ways with great outcomes. Check out their work.
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The ability to deliver high concentrated radiation treatment in a tightly controlled area at the time of surgery really allows us to customize and individualize cancer treatment for our patients. Dr. Adam J. Luginbuhl, MD

Otolaryngology/Head & Neck Surgery - Head & Neck Cancers, Thomas Jefferson University Hospital